d) Reduction of SHBG:
An important mechanism of action of some anabolic steroids often ignored by most users, is in its ability to reduce levels of SHBG (Sex Hormone Binding Globulin). Testosterone unbound (free) has biological activity while bound to SHBG is inactive. The SHBG acts as a modulator of secretion androgenic in tissues. Thus, lower levels of SHBG increases the availability of androgen action, since they fail to bind thereto. So if you do only one testosterone cycle and SHBG levels are high you lose effectiveness of steroids cycle, since part of the testosterone will bind to SHBG. You can increase the efficiency of the cycle added a drug that reduces SHBG, and other additional effects of the drug logically. Examples of steroids that significantly reduce SHBG: stanozolol, Turinabol, proviron, anadrol.
Bodybuilding is a kind of physical activity, in which special attention is paid to the beauty of the human body and the volume of muscle mass. To the muscles were effectively “traced”, athletes often resort to the use of anabolic steroids. The impact of these substances on the human body has two sides. With one, steroids help build muscle mass, reduce fat deposits, strengthen bone tissue. This is important for people involved in bodybuilding. But, on the other hand, there is such a phenomenon as androgenic activity, in which there is a masculinization, or “affirmation” of the fair sex, who use anabolic steroids.
Androgens are responsible for the growth spurt of adolescence and for the eventual termination of linear growth, which is brought about by fusion of the epiphyseal growth centers. In children, exogenous androgens accelerate linear growth rates but may cause a disproportionate advancement in bone maturation. Use over long periods may result in fusion of the epiphyseal growth centers and termination of growth process. Androgens have been reported to stimulate the production of red blood cells by enhancing the production of erythropoeitic stimulating factor. During exogenous administration of androgens,Â endogenous testosterone Â release is inhibited through feedback inhibition of pituitary luteinizing hormone (LH).