Flonase is actually a medication called fluticasone propionate. Long before it became popular for treating stuffy nose, it was used to treat Crohn's disease (a condition causing irritation that "skips" along the digestive tract), ulcerative colitis (a similar condition that doesn't "skip" but causes continuous areas of inflammation), another digestive tract problem called esinophilic esophagitis, nasal polyps, and asthma. Like Nasacort, Flonase is a potent steroid drug that can rapidly reduce swelling and inflammation of mucosal linings of the nose and throat. Unlike Nasacort, Flonase is relatively specific and doesn't have the same potential for systemic side effects, such as:
We included five studies (663 participants with nasal polyps ), three using mometasone furoate (400 µg versus 200 µg in adults and older children, 200 µg versus 100 µg in younger children) and two using fluticasone propionate drops (800 µg versus 400 µg). We found low quality evidence relating to disease severity and nasal polyps size, with results from the high-dose and low-dose groups being similar. Although all studies reported more improvement in polyp score in the high-dose group, the significance of this is unclear due to the small size of the improvements.