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To make things even more confusing, there’s also some potentially negative consequences of high doses of chlorogenic acid found in coffee. When consuming high levels, usually about twice what an average moderate coffee drinker might obtain, it’s possible that homocysteine levels in the blood could go up. Homocysteine is a nasty inflammatory molecule that is believed to be a risk factor for heart disease, heart attacks and strokes. The same effects can happen from drinking very high amounts of tea, for example, about two liters a day (which is unrealistic in most cases).