Steroid and antibiotic eye drops - hydrocortisone/neomycin/polymixin B; loteprednol/tobramycin; prednisolone/gentamycin; prednisolone/sulfacetamide; hydrocortisone /neomycin/bacitracin/ polymyxin B (Blephamide, Catapred [discontinued], Isopto, Pred-G, Poly-Pred [discontinued], Tobradex, Zylet and many other brands) are steroid and antibiotic eye drops prescribed to prevent or treat eye infections that are associated with inflammation. Side effects, drug interactions, dosage, and pregnancy safety information should be reviewed prior to using these medications.
Meibomian gland dysfunction is caused by the blockage of the meibomian glands in the eyelid. As a result, they don’t secrete enough oil into the tears to keep the eyes moist. This causes the tears to then evaporate too quickly, making it a leading cause of dry eye syndrome. Options for relief include manual gland probing (a doctor presses the hardened gland open with an instrument), antibacterial eye drops, and modifying the body’s immune response with a drug called Cyclosporine. Dipyridamole pinguecula eye drops have also proven effective for this condition, and have no known side effects.
Corticosteroids will inhibit phospholipase A2 thereby preventing the generation of substances which mediate inflammation, for example, prostaglandins. Corticosteroids also produce a marked, though transient, lymphocytopenia. This depletion is due to redistribution of the cells, the T lymphocytes being affected to a greater degree than the B lymphocytes. Lymphokine production is reduced, as is the sensitivity of macrophages to activation by lymphokines. Corticosteroids also retard epithelial regeneration, diminish post-inflammatory neo-vascularisation and reduce towards normal levels the excessive permeability of inflamed capillaries.